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As a backend system grows in size and complexity, maintaining good performance and scalability becomes a challenge, particularly when code quality has to be taken into consideration. Initially, even a little inefficiency in a database query, an API endpoint implementation, or anything else may go unnoticed. But, as your user base expands and data accumulates, such bottlenecks develop and lead to bigger problems. In order to keep the backend responsive, efficient, and capable of supporting an ever-evolving front-end, some good database handling, asynchronous processing, caching mechanisms, and data-on-demand strategies are practiced. 

Implementing these strategies from the start will spare your system from unnecessary load and downtime, whether it is dealing with thousands of records or millions of users. In this guide, we will attempt an outline of key backend optimization strategies, starting with methods to cut down unnecessary redundant database queries, such as Django's select_related() and prefetch_related(). We'll explore offloading heavy-laden tasks to background workers like Celery and discuss efficient file serving, API response tuning strategies, and how to profit from Redis, CDNs, and cloud storage solutions. Equipped with these strategies, you will be much more prepared to develop a robust, scalable backend capable of going up in size without compromising in speed or stability.

Dealing with large projects, performance and scalability can be maintained without compromising code quality is a big task. The more traffic you get, and the larger the codebase is, the greater the chance that small inefficiencies can result in the appearance of large issues. Below are the main suggestions which enable the performance and scalability of your backend to be improved:

1. Enhance Database Queries

Use select_related() and prefetch_related(): These Django methods help reduce the query count by effective handling of related data (for example, foreign keys or many-to-many relationships).

Filter Only the Needed Data: Use.only() or.values() to only return the fields you need to save memory and processing time.

Add Indexes: Creating indexes on columns that are frequently filtered or sorted upon (with django.db.models.Index) in Django can improve queries.

Prevent Excessive Data in APIs: Make sure your API returns only necessary data to prevent unwanted load.

2. Use Caching

Caching of data that is accessed often in a fast in-memory cache like Redis or Memcached lowers database load, lowers response time, and improves performance.

3. Offload Heavy Work to Background Jobs

For long-duration operations (like sending an email, image processing, or creating a report), use background workers instead of executing them inside the request-response cycle. You can use tools like Celery with Redis or RabbitMQ to help you process such operations asynchronously without making your application slow.

4. Optimize API Responses

Use Pagination: Avoid sending large amounts of data in a single API response. Send small, bite-sized data in chunks using pagination, improving load times and server performance.

5. Process Large Files Efficiently

Use Specialized File Storage: Let services such as Amazon S3 or Google Cloud Storage store and deliver large files (such as videos or high-quality images). They are better equipped to store large files than your server.

Download Upon Streaming: A video should be streamed using HLS or DASH to make it easier to play without preloading altogether. 

File Download Optimization: Set appropriate headers to enable good caching for download speed and therefore include a Content-Disposition header to suggest how the browser should treat the file.

Use a CDN: Relocate file distribution to a Content Delivery Network (CDN), where files are cached in edge locations to distribute them more quickly to users.